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IMMUNOGLOBULIN FC FRAGMENTS
Descriptors Found:
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DeCS
Descriptor
English
:
Immunoglobulin Fc Fragments
Descriptor
Spanish
:
Fragmentos Fc de Inmunoglobulinas
Descriptor
Portuguese
:
Fragmentos Fc das Imunoglobulinas
Synonyms
English
:
Fc Fragments
Fc Immunoglobulins
Tree Number:
D12.644.541.500.697
D12.776.124.486.485.538.500
D12.776.124.486.485.680.697
D12.776.124.790.651.538.500
D12.776.124.790.651.680.660
D12.776.377.715.548.538.500
D12.776.377.715.548.680.660
Definition
English
:
Crystallizable fragments composed of the carboxy-terminal halves of both
IMMUNOGLOBULIN HEAVY CHAINS
linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the
cell membrane
via
FC RECEPTORS
, and placental transport). This fragment can be obtained by
digestion
of
immunoglobulins
with the proteolytic enzyme
PAPAIN.
Indexing Annotation
English
:
DF: IG FC
Pharmacological Action:
Immunologic Factors
See Related
English
:
Receptors, Fc
History Note
English
:
2006 (1973)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CH
chemistry
CL
classification
CT
contraindications
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22215
Unique Identifier:
D007141
Occurrence in VHL
:
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